"Parkinson's and Alzheimer's disease are now the two most common neurodegenerative disorders. They develop after a progressive death of many neurons in the brain. Although therapies are available to treat the signs and symptoms of both diseases, the progression of neuronal death remains relentless, and it has proved difficult to slow or stop. Hence, there is a need to develop neuroprotective or disease-modifying treatments that stabilize this degeneration. Red to infrared light therapy (? = 600–1070 nm), and in particular light in the near infrared (NIr) range, is emerging as a safe and effective therapy that is capable of arresting neuronal death. Previous studies have used NIr to treat tissue stressed by hypoxia, toxic insult, genetic mutation and mitochondrial dysfunction with much success. " Source

Neurodegeneration refers to a progressive death of neurons, by either genetic environmental or currently unknown factors. It includes a range of disorders, with the two most common being Alzheimer's and Parkinson's disease. Over time, as more and more neurons die, the signs and symptoms associated with each disorder worsen, making many routine day-day activities increasingly more difficult for patients (Tierney et al., 2013; Schapira et al., 2014; Brettschneider et al., 2015; Coppedè and Migliore, 2015; Goedert, 2015; Herrup, 2015; Nelson and Tabet, 2015

Alzheimer's Disease

Alzheimer's disease is the name given to an age-related, insidious-onset, progressive dementia. Individuals suffer progressive memory and cognitive decline and an overall loss of executive function (Herrup, 2015; Nelson and Tabet, 2015).

Parkinson's Disease

The clinical syndrome and neuropathology of Parkinson's disease are very different to Alzheimer's disease. Parkinson's patients have predominately motor signs, including resting tremor, lead-pipe rigidity, akinesia, and/or bradykinesia (Bergman and Deuschl, 2002; Jankovic and Poewe, 2012).

Mainly due to the existence of effective toxin-based in vitro and in vivo models, there have been considerably more reports on the beneficial effects of NIr near-infrared for Parkinson's disease.

"The application of red to near-infrared (LED) light (k=600–1070 nm) to body tissues, known also as photobio-modulation (PBM), has been used to treat many neurological conditions in humans, including Parkinson’s disease, Alzheimer’s disease, depression, traumatic brain inju-ry, age-related macular degeneration, stroke, and lower back pain. In each of these explorations, as in all those involving experimental animals, PBM leads to bene-ficial outcomes, including improved cognition, mood, sight,memory, and movement.A key feature of PBM" Source

Can Transcranial red light improve Parkinson’s disease symptoms?

"Parkinson’s disease is a neurological disorder with distinct signs of resting tremor, akinesia and/or lead-pipe rigidity, together with non-motor symptoms of impaired smell, cognition and autonomic function. These manifest after a major degeneration of neurones mainly within the brainstem,(Johnstone et al., 2016; Mitro-fanis, 2017)

What Would be the Advantages of Using NIr Therapy?

"There would be several key advantages for the use of NIr therapy over current treatments for both Alzheimer's and Parkinson's disease. First and foremost, NIr has the potential to be neuroprotective. A growing body of pre-clinical evidence indicates that NIr therapy slows or stops disease pathology (Liang et al., 2008; Ying et al., 2008; Shaw et al., 2010; Peoples et al., 2012; Moro et al., 2013; Purushothuman et al., 2013, 2014, 2015; Johnstone et al., 2014b; El Massri et al., 2015; Reinhart et al., 2015a,b)"

A number of recent studies have shown that photobiomodulation, the use of red to infrared light (? = 600–1070 nm) on body tissues, has beneficial effects in many animal models of Parkinson’s disease, from flies to monkeys (Hamblin, 2016; Johnstone et al., 2016; Mitrofanis, 2017).

Red and near infrared and the production of mesenchymal stem cells, MSCs.

These benefits include, a restoration of the abnormal neu-ronal activity in the basal ganglia, an improvement in loco-motive behaviour and reduction in clinical signs, as well as an increase in the survival patterns of neurones damaged by either the parkinsonian toxin or the genetic mutation of the model used.

As it stands, there are early indications that photobio-modulation has beneficial effects on Parkinson’s disease pa-tients. Several clinical case reports have used a transcranial approach, with either a hand-held laser or light emitting device (LED) or a helmet lined with many LED strips cov-ering the bulk of the head

There is a clinical report indicating improved speech, cognition, freezing episodes and gait in eight parkinsonian patients after a two week application of photobiomodulation across the head (Maloney et al., 2010)

In addition, from a study of thirty six patients, photobiomod-ulation from an intranasal device resulted in improvements in the majority of parkinsonian signs (~90%) after treatment for thirty minutes per day for ten days (Zhao et al., 2003).

photobiomodulation has been shown to influence immune and stem cell function in experimental animals (Muili et al., 2012; Oron and Oron, 2016)

Why and how does light therapy offer neuroprotection in Parkinson’s disease?

The “hard” scientific evidence that photobiomodu-lation does indeed change neuronal activity and influence neuronal survival against insult has become irrefutable (Hamblin, 2016). Source

Of the initial signs and symptoms, including tremor, akinesia, gait, difficulty in swallowing and speech, less facial animation and reduced fine motor skills, smell and social confidence, ~75% showed overall improvement, ~25% stayed the same and none got worse. For the majority of these signs and symptoms, changes were assessed by either the patient themselves, their carers or their attending medical practitioners.

Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease

The penetration of light into the human body varies. Light at the Red end of the color spectrum penetrates deeper than light at the Blue end of the spectrum. NASA reported on their research using NASA LEDs commenting that,“ wavelengths of 630–800 nm [red and NIR] travel approximately 23 cm [approx. 9”] through the skin surface

The growth of human scalp hair in females using visible red light laser and LED sources

Forty-seven females (18–60 years old, Fitzpatrick I–IV, and Ludwig–Savin Baldness Scale I-2, I-3, I-4, II-1, II-2 baldness patterns) were recruited. A transition zone scalp site was selected; hairs were trimmed to 3?mm height; the area was tattooed and photographed. The active group received a unit containing diode lasers and 30 LEDS
Conclusions
LLLT of the scalp at 655nm significantly improved hair counts in women with androgenetic alopecia at a rate similar to that observed in males using the same parameters.

Skin issues
"Red light therapy aims to solve skin issues by using low wavelength red light. Many experts believe that it can help with issues such as skin conditions, scarring, and signs of aging — including wrinkles and age spots.As a study in the journal Seminars in Cutaneous Medicine and Surgery notes, mitochondria in the skin cells can absorb these light particles. This can help the cells produce more adenosine triphosphate, which is the energy source for cells. Many experts attribute the potential positive benefits to this function. With this extra energy, the cells may be able to respond better to damage and rejuvenate themselves"

It will stimulate the re-growth of collagen. Collagen is an essential protein used to repair damaged tissue and replace old tissue.

"Wound healing It has been found that infrared light releases nitrous oxide in the blood stream which increases the circulation of blood in the area where the light is directed. This is very helpful for people, who due to various diseases such as Diabetes find it very difficult to heal wounds on the surface of the skin. This is also helpful for patients suffering with Neuropathy, Ulcers and for patients whose blood circulation is improper.
" Red light may also be helpful in speeding up wound healing. Research in the journal Anais Brasileiros de Dermatologia highlights the fact that light therapy may help wound healing in a few ways, such as by:
reducing inflammation in the cells "
The use of red light in skin treatment,treats deeper pores. Red light can travel further into the skin than blue light. It can also generate heat at the level of the sebaceous glands,it can shrink the glands and reduce sebum production. Source

Reducing pain A review in the European Journal of Physical and Rehabilitation Medicine compiled the results of many studies surrounding RLT and musculoskeletal disorders.

Alopecia A study in the Journal of Cosmetic and Laser Therapy explored the effect of light on people with alopecia.

Anti-inflammatory benefits As research in the journal AIMS Biophysics notes, many of the conditions that RLT treats have their roots in inflammation.

Is NIr Therapy Safe?
To date, there are no reports of major safety issues nor side-effects after NIr treatment. The commercial LED panels for NIr therapy have already received non-significant risk status by the Food and Drug Administration and previous studies have indicated no adverse impact on brain tissue structure and function after NIr treatment (power range from ~1 to 700 mW/cm2; Desmet et al., 2006; Hamblin and Demidova, 2006; Ilic et al., 2006; Zivin et al., 2009; McCarthy et al., 2010; Naeser et al., 2011, 2014; Rojas and Gonzalez-Lima, 2011; Chung et al., 2012; Tata and Waynant, 2012; Quirk et al., 2012a,b; Moro et al., 2014)

Parkinsons Rife Machine Frequencies

These are not just LED's they are Deep penetrating LASERS

Laser Beam Cap 92 Beam Laser Cap Alzheimer's and Parkinson's. Wound healing Neurodegeneration Skalp and Skin issues Anti-inflammatory benefits Red and near infrared and the production of mesenchymal stem cells, MSCs Instructions Skype backup More information

Some Published Rife Frequencies

These frequencies can be added to your Rife Machine and saved on its hard drive

Rife machine frequencies :Parkinson's disease (a slowly progressive, degenerative,
neurologic disorder): 813

Rife machine frequencies Parkinson Disease: 0.08, 0.35, 0.65, 0.83, 9.50, 115.71, 255.83, 485.43, , 644, 692.50, 813, 825. 978.05. 986, 6000Hz

Rife machine frequencies Parkinsonian Disorders: 0.57, 0.78, 0.90, 5.25, 7.00, 115.71, 255.83, 485.43, 692.50, 813, 825.Hz

Rife machine frequencies Wolff-Parkinson-White Syndrome: 0.08, 0.55, 7.50, 8.00, 12.33, 96.50, 175.16, 410.25, 642.91, 978.05

Rife machine frequencies Mycoplasma fermentans (exp. May be a factor in chronic fatigue, alzheimer's, parkinson's, and MS) - 2900, 864, 790, 690, 610, 484, 986, 644, 254

Rife machine frequenciy 6000 - A master Central Nervous System Frequency. Release of emotional problems, blocked seizures - but does nothing once seizure starts, repoertedly stopped tremors in hands in person with Parkinson's disease.

Rife machine frequencies for Parkinson tremor, temporary relief - 6000 for 10 min, 130, 169

Rife machine frequencies for Parkinson's disease (a slowly progressive, degenerative, neurologic disorder, also use Chlamydia pneumoniae and see Nocardia asteroides freqs) -693, 813, 1.1, 5000, 1131 for 3 min, 33 for 30 min

Red Light Infrared LED Therapy cap
(Not as Deep penetration as the Laser cap)

Red light therapy, also called photobiomodulation or low-level light therapy, is the process of diffusing concentrated wavelengths of natural light into the skin to treat various ailments and conditions and to otherwise improve the circulation and functioning of the cells.

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Sources

Professor John Mitrofanis (University of Sydney) and Professor Alim Louis Benabid (CEA-LETI Grenoble University) have been research collaborators for some years now, investigating the effects of near infrared light on the dopamine-producing cells damaged by Parkinson’s Disease.

Based on the work of Dr Frank Nicklason, Dr Catherine Hamilton, Prof John Mitrofanis, Nabil el Massri and David Hamilton.
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