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Oxidative Stress And Inflammation Age Humans The Fastest

Stress wreaks havoc on the mind and body. Until now, it has not been clear exactly how stress influences disease and health. Now researchers have found that chronic psychological stress is associated with the body losing its ability to regulate the inflammatory response. The research shows for the first time that the effects of psychological stress on the body's ability to regulate inflammation can promote the development and progression of disease

"Did you know that inflammation is the common link between such debilitating conditions as Alzheimers, heart disease, cancer, and arthritis?
Did you know inflammation is thought to be the culprit behind the visible signs of aging? Inflammation is a wellness buzz-word these days, and for good reason. If you reduce inflammation in your body, you'll not only look and feel younger, but you'll significantly lower your risk for chronic disease!" Source

Stress wreaks havoc on the mind and body. For example, psychological stress is associated with greater risk for depression, heart disease and infectious diseases. But, until now, it has not been clear exactly how stress influences disease and health.

Chronic Inflammation Is Like a Fire Raging Inside Your Body !!!

When we feel threatened, our fight or flight response the body’s stress response kicks in and makes changes in the body. The heart rate quickens, stress hormones like cortisol are released, and a host of other changes occur that allow the body a quick burst of energy to run away fast or stay and fight — strategies that have worked for thousands of years, but aren’t always practical now. While that burst of energy and alertness can cause you to act, if your body remains in this state for prolonged periods of time (as in the case of chronic stress), it can be damaging to your health in many ways.

Chronic inflammation is when your body no longer has the ability to turn off the inflammatory response and it starts damaging healthy tissue in your body.

"Researchers found that chronic stress changes gene activity of immune cells before they enter the bloodstream so that they’re ready to fight infection or trauma — even when there is no infection or trauma to fight. This then leads to increased inflammation,reported the researchers from Ohio State University, the University of California, Los Angeles, Northwestern University and the University of British Columbia. "

A research team led by Carnegie Mellon University's Sheldon Cohen has found that chronic psychological stress is associated with the body losing its ability to regulate the inflammatory response. Published in the Proceedings of the National Academy of Sciences, the research shows for the first time that the effects of psychological stress on the body's ability to regulate inflammation can promote the development and progression of disease.

“There is a stress-induced alteration in the bone marrow in chronically stressed humans that selects for a cell that’s going to be pro-inflammatory,” study researcher John Sheridan, a professor at Ohio State University and associate director of the university’s Institute for Behavioral Medicine Research, said in a statement. “So what this suggests is that if you’re working for a really bad boss over a long period of time, that experience may play out at the level of gene expression in your immune system.”

"Inflammation is partly regulated by the hormone cortisol and when cortisol is not allowed to serve this function, inflammation can get out of control," said Cohen, the Robert E. Doherty Professor of Psychology within CMU's Dietrich College of Humanities and Social Sciences." In short, the theory is that with our ever-stressed, fast-paced lifestyle, our bodies are pumping out cortisol almost constantly, which can wreak havoc on our health

Cohen argued that prolonged stress alters the effectiveness of cortisol to regulate the inflammatory response because it decreases tissue sensitivity to the hormone. Specifically, immune cells become insensitive to cortisol's regulatory effect. In turn, runaway inflammation is thought to promote the development and progression of many diseases.

"Weight Gain and Obesity

"Experts now believe that the problem for many of us is being in a constant state of stress. Exposure to cortisol over the long term can lead to weight gain, as your appetite and insulin levels are continuously increased. If stress and cortisol levels stay high, so will insulin levels, says Robert M. Sapolsky, Ph.D., a professor of biological sciences and neuroscience at Stanford University. Continual stress leads to a constant state of excess cortisol production, which stimulates glucose production. This excess glucose then typically is converted into fat, ending up as stored fat. According to Dr. Sapolsky, "The net effect of this will be increased fat deposition in a certain part of the body." Furthermore, according to the authors of the book The Cortisol Connection, stress and the resulting chronic overload of cortisol, make you feel tired and listless. So you overeat to renew your energy and comfort yourself, with the end result of accumulated extra inches around the middle". Source

Cohen, whose groundbreaking early work showed that people suffering from psychological stress are more susceptible to developing common colds, used the common cold as the model for testing his theory. With the common cold, symptoms are not caused by the virus -- they are instead a "side effect" of the inflammatory response that is triggered as part of the body's effort to fight infection. The greater the body's inflammatory response to the virus, the greater is the likelihood of experiencing the symptoms of a cold.

In Cohen's first study, after completing an intensive stress interview, 276 healthy adults were exposed to a virus that causes the common cold and monitored in quarantine for five days for signs of infection and illness. Here, Cohen found that experiencing a prolonged stressful event was associated with the inability of immune cells to respond to hormonal signals that normally regulate inflammation. In turn, those with the inability to regulate the inflammatory response were more likely to develop colds when exposed to the virus.

When we are "nice" at the expense of our health, we set ourselves up to develop disease. Civilization has it's price. We cannot afford to allow situations to continually gnaw at our insides in silence. "Every doctor is familiar with the ""cancer personality"" .... "The nicest person in the world" say his friends and relatives, "This should not have happened to him" (Dr. Kennedy).

In the second study, 79 healthy participants were assessed for their ability to regulate the inflammatory response and then exposed to a cold virus and monitored for the production of pro-inflammatory cytokines, the chemical messengers that trigger inflammation. He found that those who were less able to regulate the inflammatory response as assessed before being exposed to the virus produced more of these inflammation-inducing chemical messengers when they were infected.

"The immune system's ability to regulate inflammation predicts who will develop a cold, but more importantly it provides an explanation of how stress can promote disease," Cohen said. "When under stress, cells of the immune system are unable to respond to hormonal control, and consequently, produce levels of inflammation that promote disease. Because inflammation plays a role in many diseases such as cardiovascular, asthma and autoimmune disorders, this model suggests why stress impacts them as well."

He added, "Knowing this is important for identifying which diseases may be influenced by stress and for preventing disease in chronically stressed people."

Remember, it is the immune system that fights cancer and stress is devastating to our immune system. This may be the most difficult area of managing our lives in order to get well. We can be loyal to our Beliefs at the expense of our health. I have seen it over and over again. Folks just can't convince themselves that certain drastic changes may be in order for them to manage their recovery well.

A recent study conducted by researchers at Yale University compared women who stored fat primarily in their abdomens with women who stored it mostly in their hips. They found that the women with belly fat reported feeling more threatened by stressful tasks and having more stressful lives. They also produced higher levels of cortisol than the women with fat on their hips. And that, the authors reasoned, suggests that cortisol causes fat to be stored in the center of the body.
Epel ES, McEwen B, Seeman T, Matthews K, Castellazzo G, Brownell KD, Bell J, Ickovics JR. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. Source

Do you have any of these Physical signs
Dizziness, general aches and pains, grinding teeth, clenched jaws, headaches, indigestion, muscle tension, difficulty sleeping, racing heart, ringing in the ears, stooped posture, sweaty palms, tiredness, exhaustion, trembling, weight gain or loss, upset stomach

Mental signs
Constant worry, difficulty making decisions, forgetfulness, inability to concentrate, lack of creativity, loss of sense of humor

"By the way, autism, fibromyalgia, IBS and even cancer can all be boiled back to factories and labs concocting the ways and means to damage human cells. Did you know that multiple sclerosis (MS) is a chronic, inflammatory disease in which the myelin sheath (on the nerve endings) gets INFLAMED and thus damaged?"

Emotional signs
Anger, anxiety, crying, depression, feeling powerless, frequent mood swings, irritability, loneliness, negative thinking, nervousness, sadness

Behavioral signs
Bossiness, compulsive eating, critical attitude of others, explosive actions, frequent job changes, impulsive actions, increased use of alcohol or drugs, withdrawal from relationships or social situations

A lecturer, when explaining stress management to an audience, raised a glass of water and asked,

'How heavy is this glass of water?'

Answers called out ranged from 20g to 500g.

The lecturer replied, 'The absolute weight doesn't matter. It depends on how long you try to hold it.
If I hold it for a minute, it's not a problem..
If I hold it for an hour, I'll have an ache in my right arm. If I hold it for a day, you'll have to call an ambulance.
In each case, it's the same weight, but the longer I hold it, the heavier it becomes.'

He continued, 'And that's the way it is with stress management. If we carry our burdens all the time, sooner or later, the burden will become increasingly heavy: and we won't be able to carry on. '

'As with the glass of water,
you have to put it down for a while and rest before holding it again.

Cranial electrostimulation therapy (CES)

CES A Unique Non-drug Therapy

CES is a simple treatment employing mild battery-powered electronic stimulation through clip-on electrodes that attach to the earlobes or by pre-gelled electrodes placed behind the ears. Current flow is limited so that the most a user will experience during the process is a brief tingling sensation. Its most immediate impact is reduction of anxiety. For most people, anxiety reduction is experienced in the course of treatment, but it also may be first seen hours, or as late as several days after. After a CES session you are left feeling both alert and relaxed . Psychologists call this an "alpha state". The effect differs from pharmaceutical treatments in that people report feeling that their bodies are lighter and more relaxed and their mind more alert and clear. The results are cumulative and lasting.

"There’s no escaping it: stress is a part of our lives. How we handle that stress can have an impact on our health. Every day, we hear more and more about the harm it may cause our minds and bodies,- from heart disease to anxiety attacks. Now researchers are trying to determine if stress is also a factor in who will develop cancer."

Hundreds of studies have measured how stress impacts our immune systems and fights disease. At Ohio State University, researcher Dr. Ron Glaser, Ph.D., found that students under pressure had slower-healing wounds and took longer to produce immune system cells that kill invading organisms. Renowned researcher Dr. Dean Ornish, M.D., who has spent 20 years examining the effects of stress on the body, found that stress-reduction techniques could actually help reverse heart disease. And Dr. Barry Spiegel, M.D., a leader in the field of psychosomatic medicine, found that metastatic breast cancer patients lived longer when they participated in support groups.

Other studies have gone as far as to show those women who experienced traumatic life events or losses in previous years had significantly higher rates of breast cancer. Source

CES is the doorway to good health.

82% of participants in one study suffering from an anxiety/Stress reported a significant improvement in their symptoms after treatment with CES.
- Kirsch D, Gilula MF, Electromedicine: CES in the Treatment of Anxiety Disorders, Practical Pain Management, March 2007, pp 40-47.

It works as an important adjunct in programs invoking nutrients, hormones, and medications. Its multiplicity of health benefits include: induction of relaxation response; exertion of control over frontal lobe behavior and modulating hormone levels...When amino acid supplementation is coupled with CES therapy, this combination is not only a potentially potent therapeutic regimen for stress but anti-aging as well

"Some don't understand how great Cranial Electrical Stimulation is Then there are others who will try to scare you by saying there is terrible side effects. It is just not true!!! It has been FDA approved for the past 27 years as a class 2A medical device, with one of the best safety rating."

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If your Stress levels have or are Causing Inflammation

The Use of Magnetic Field for the Reduction of Inflammation:

Electromagnetic fields are the basis of all life. The earth possesses a magnetic field which is the prerequisite for the survival of all life forms. The human body, like every other organism, functions by way of a finely co-ordinated network of electromagnetic fields and forces. These regulate most bodily functions and keep them in their natural equilibrium.

"Normal cells are not usually impacted by magnetic fields. Compromised cells, called meta-stable cells, are more likely to be impacted. This means that PEMFs have more impact in circumstances where there is imbalance in tissues or cells, ie, where there is pathology or chronic inflammation."

Increased Oxygen Supply
- In aerobic cell respiration (increased stamina in athletic performance)
- In anaerobic cell respiration (more rapid regeneration as a result of expulsion of lactates and faster incorporation of glycogens into muscle cells)
- General increase in metabolism owing to increase in combustion processes within the cells (mitochondria)

Improved Circulation
- Circulatory problems: in vascular disease caused by diabetes and sclerosis (arteriosclerosis), in varicose veins with ulcers
- Accelerated absorption of bruises (haematomas)
- Expulsion of lymph oedema

Reduction of inflammation by PEMFs

Significant changes occur in other white blood cells called lymphocytes, from both low intensity, low-frequency PEMF’s and even DC/permanent magnetic fields. PEMFs interact with cellular systems in often unexpected ways. This means that increasing frequency and or intensity does not always produce a one-to-one change in reaction intensity.

PEMF’s inhibit growth and the natural death of unwanted lymphocytes that decreases inflammation. The EMF inhibition of lymphocytes and then inflammatory processes appears to be most obvious 48 and 72 hours after EMF treatment and then the EMF effect seems to disappear. This indicates that the effects of PEMFs can work well with other natural treatments.

"PEMF therapy targets cells that are meta-stable as a consequence of disease or other ongoing therapies. Thus, PEMF’s can be an important cellular therapy in many diseases, including cancer, psoriasis, wound healing, and bacterial infections because of their effects on reducing chronic inflammation. It is important that normal homeostatically stable cells are not harmed by PEMF’s, allowing other treatments to be more effective without proportional increases in side effects. In chronic inflammatory diseases, cells are characteristically maintained in meta-stable states, as a consequence of cytokine secretions and other stressors associated with the disease. In these cases, PEMF’s can work as a stand-alone anti-inflammatory therapy. Even weak, low-frequency PEMF’s induce apoptosis in activated T cells, thereby reducing chronic inflammation without negatively affecting normal body process"

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Oxidative Stress

Oxidative Stress And Inflammation Age Humans The Fastest

Like an apple turns brown when exposed to air, our cells can “rust” when we breathe due to oxidative stress, a process caused by free radicals. Free radicals are unstable molecules that damage or “oxidize” cells throughout the body in a process called oxidative stress.

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases such as atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, stroke ..

"When people hear the term neurodegenerative disease, they either run the other way and just pray that they never have to deal with it, or they have no idea what it means. When millions of Americans take prescription drugs to cover up and temporarily minimize symptoms of chronic health ailments, they are actually increasing oxidative stress and inflammation, pouring “salt in the wound.” Finally, when people consume chemicals in foods and drinks, and use chemical-laden personal care products, they are fueling the degeneration of their DNA, and when that incapacitates the brain, they can’t even identify their immediate family. It’s called Alzheimer’s disease, and it’s not just for “old timers” anymore."

"Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants.

Free radicals can chemically interact with cell components such as DNA, protein or lipid and steal their electrons in order to become stabilized. This, in turn, destabilizes the cell component molecules which then seek and steal an electron from another molecule, therefore triggering a large chain of free radical reactions.

Every cell that utilizes enzymes and oxygen to perform functions is exposed to oxygen free radical reactions that have the potential to cause serious damage to the cell. Antioxidants are molecules present in cells that prevent these reactions by donating an electron to the free radicals without becoming destabilized themselves. An imbalance between oxidants and antioxidants is the underlying basis of oxidative stress.

Oxidative stress leads to many pathophysiological conditions in the body. Some of these include neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, gene mutations and cancers, chronic fatigue syndrome, fragile X syndrome, heart and blood vessel disorders, atherosclerosis, heart failure, heart attack and inflammatory diseases." By Dr Ananya Mandal, MD

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Multiwave oscillators

Rife machines and Multiwave oscillators are claimed to complement each other based on the principle that life forms absorb energy. A multiwave Oscillator uses this principle to strengthen cells within the body to resist disease while a Rife machine uses this principle to destroy microorganisms with an overdose of frequency energy.

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In addition to Cohen, the research team included CMU's Denise Janicki-Deverts, research psychologist; Children's Hospital of Pittsburgh's William J. Doyle; University of British Columbia's Gregory E. Miller; University of Pittsburgh School of Medicine's Bruce S. Rabin and Ellen Frank; and the University of Virginia Health Sciences Center's Ronald B. Turner.

The National Center for Complementary and Alternative Medicine, National Institute of Mental Health, National Heart, Lung and Blood Institute and the MacArthur Foundation Research Network on Socioeconomic Status and Health funded this research.

Carnegie Mellon University
The above post is reprinted from materials provided by Carnegie Mellon University. Note: Materials may be edited for content and length.

Journal Reference:

Sheldon Cohen, Denise Janicki-Deverts, William J. Doyle, Gregory E. Miller, Ellen Frank, Bruce S. Rabin, and Ronald B. Turner. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. PNAS, April 2, 2012 DOI: 10.1073/pnas.1118355109

Carnegie Mellon University. "How stress influences disease: Study reveals inflammation as the culprit." ScienceDaily. ScienceDaily, 2 April 2012. sciencedaily.com/releases/2012/04/120402162546.htm

-Eric Braverman, M.D.
Director, PATH Medical
Author, The Edge Effect

Dr Pawluk