In 1967, a few years after the first working laser was invented, Endre Mester in Semmelweis University, Budapest, Hungary wanted to test if laser radiation might cause cancer in mice [1]. He shaved the dorsal hair, divided them into two groups and gave a laser treatment with a low powered ruby laser (694 nm) to one group. They did not get cancer, and to his surprise the hair on the treated group grew back more quickly than the untreated group. This was the first demonstration of "laser biostimulation". Since then, medical treatment with coherent-light sources (lasers) or non coherent light (light-emitting diodes, LEDs) has passed through its childhood and adolescence. Currently, low-level laser (or light) therapy (LLLT), also known as "cold laser", "soft laser", "biostimulation" or "photobiomodulation" is practiced as part of physical therapy in many parts of the world. In fact, light therapy is one of the oldest therapeutic methods used by humans (historically as solar therapy by Egyptians, later as UV therapy for which Nils Finsen won the Nobel prize in 1904 [2]). The use of lasers and LEDs as light sources was the next step in the technological development of light therapy, which is now applied to many thousands of people worldwide each day.

LLLT mechanism and application. Incoming red and NIR photons are absorbed in cell mitochondria, producing reactive oxygen species (ROS) and releasing nitric oxide (NO), which leads to gene transcription via activation of transcription factors (NF-?B and AP1). Source

Low-level lasers are also called cold lasers, soft lasers, biostimulation lasers, low-intensity lasers, etc.

Low-level laser therapy (LLLT) is the use of a low-powered laser that emits specific wavelengths of light in the visible red and/or far infrared range for therapeutic purposes. This involves the application of low power light to areas of the body in order to stimulate healing. It is also known as cold laser, soft laser or low intensity laser.

The reason why the technique is termed LOW-level is that the optimum levels of energy density delivered are low when compared to other forms of laser therapy as practiced for ablation, cutting, and thermally coagulating tissue. more

Controlled research into the effects of low level laser is currently being conducted in various European centres and in Japan.

Knee injuries and conditions treated by low-level laser include tendonitis, bursitis, meniscus tears, runners knee/chondromalacia patella, knee joint effusion, iliotibial band syndrome, osgood schlatters disease, osteoarthritis and rheumatoid arthritis.

Low-level powers use very low power and no heating of or damage to the tissue occurs. Low-level laser treatment increases cell metabolism.

Low-level lasers emit light in the red and infrared range. Red and infrared light penetrate deeply into human tissue, where the light energy is absorbed and turned into biochemical energy. By increasing cellular energy in the treated area, low-level laser therapy is believed to speed healing and reduce inflammation and pain. There are no known side effects

lasers are not magical; it is the light that they produce that yields the biological effect

How does it work?

Photons, which are particles of electromagnetic energy, are emitted from the low power laser. These particles enter the tissues and are absorbed in the mitochondria, which are tiny structures within the substance of each individual cell. The energy is converted to chemical energy within the cell. The permeability of the cell membrane changes which in turn produces various physiological effects. These physiological changes affect a variety of cell types including macrophages, fibroblasts, endothelial cells and mast cells.

Low-level laser therapy (LLLT)/ Photobiological techniques are sometimes less invasive than those used in other areas of science, allowing the sample to respond without incurring much damage. It is no coincidence that two of the most important macromolecules in biology - DNA and chlorophyll - respond readily to light. In fact absorption of light by plants is the driving force for much of the life on earth.

COLD LASER THERAPY is a treatment whereby a cold laser is utilized to treat chronic and acute pain. Cold laser therapy is used for persons suffering from back and neck pain, musculoskeletal pain, joint pain associated with arthritis, fibromyalgia, tendonitis, busiitis, neuropathy, Achilles tendon pain, migraine headaches, sprains and strains, carpal tunnel and other associated pains. Cold laser therapy is also used in the treatment of conditions such as TMJ, reflex sympathetic dystrophy (RSD) and other inflammatory and scarring conditions

What is it used for?

Low-power laser therapy is used by physical therapists to treat a wide variety of acute and chronic musculoskeletal aches and pains, by dentists to treat inflamed oral tissues and to heal diverse ulcerations, by dermatologists to treat edema, non-healing ulcers, burns, and dermatitis, by orthopedists to relieve pain and treat chronic inflammations and autoimmune diseases, and by other specialists, as well as general practitioners. Laser therapy is also widely used in veterinary medicine (especially in racehorse-training centers), and in sports-medicine and rehabilitation clinics (to reduce swelling and hematoma, relieve pain, improve mobility, and treat acute soft-tissue injuries). Lasers and LEDs are applied directly to the respective areas (e.g., wounds, sites of injuries) or to various points on the body (acupuncture points, muscle-trigger points).

Cold Laser therapy, whether using low intensity radiation in the visible or near-infrared region can be beneficial in a number of clinical situations, from pain remission to wound healing. Unfortunately, the absence of this type of phototherapy from the mainstream of medicine makes it unavailable to patients who could benefit from it.

Soft tissue injuries, including sprains and strains, tendonitis and haematomas
Joint conditions, including arthritis, tenosynovitis and capsulitis
Chronic pain, including Trigeminal neuralgia and chronic neck and back pain
Wound management, including skin ulcers, pressure sores and burns
Skin infections, including cold sores, warts, verruca
The laser may also be focussed on acupuncture points to assist with smoking cessation and the relief of short or long-term pain

LLLT for central nervous system (CNS) neurological disorders. NIR light can penetrate through the skull into the brain, reducing neuronal cell death, reducing inflammation and increasing the likelihood of neurogenesis. The retinal nerves and the spinal cord are classified as part of the CNS, and light is delivered for similar reasons into the eye or to the neck or back at the site of the spinal cord lesion. Source

LLLT for pain relief, inflammation and healing. In recent years, there has been growing interest in the use of laser biostimulation as a therapeutic modality for pain management (Strong, 2002). Alterations in neuronal activity have been suggested to play a role in pain relief by laser therapy.

Many published reports document the positive findings for laser biostimulation in pain management. This level of evidence relates to chronic neck pain (Chow et al., 2005), tendonitis (Bjordal et al., 2006), chronic joint disorders (Bjordal et al., 2003), musculoskeletal pain (Gerber et al., 2001), and chronic pain (Aronoff, 1999). Randomised controlled trials provide evidence for the efficacy of laser therapy in chronic low back pain (Frazer et al., 2003).

LLLT significantly improves wound healing in both diabetic rats and diabetic mice. LLLT was also effective in X-radiation impaired wound healing in mice. Furthermore, the total collagen content was significantly increased at 2 months, when compared with control wounds. The beneficial effect of LLLT on wound healing can be explained by considering several basic biological mechanisms, including the induction of the expression of cytokinesis and growth factors known to be responsible for the many phases of wound healing. Figure below shows the mechanism of LLLT on wound healing (Lucas et al., 2002).

LLLT for Wound Healing. Cells in the wound respond to light induced reactive oxygen species (ROS) leading to the expression of growth factors, such as transforming growth factor beta (TGF), and platelet derived growth factor (PDGF), which encourage synthesis of more collagen, increased formation of blood vessels, and less inflammation, all of which increase wound healing. Source

Most health care plans do not cover LLLT because the FDA considers LLLT investigational, experimental and unproven (though approved for use since 2002 by the FDA). More large clinical trials that follow stringent scientific guidelines are needed. Though there have been many trials they have been considered inadequate. (1)

Cold laser therapy increases serotonin levels which allow the body to heal itself. Cold laser therapy is non-thermal and noninvasive. A combination of cold laser and electric stimulation, cold laser therapy is one of the most effective healing therapies in the medical community today. Completed in one to three sessions, cold laser therapy is not only significant in reducing treatment times, it is cost effective as well.

Therapeutic Principle:

"Our Semiconductor Laser Therapeutic Instrument has been developed based on modern laser medicine and clinical practice. It adopts low-level laser with the wavelength of 650nm, through specific parts of irradiation and using light radiation of laser and wavelength relation to change the biological characteristics and peel off the fat layer and cholesterol in the red blood cells, to improve the activity and oxygen carrying capacity as well as the deformability of cells, reduce the concentration of middle molecules in the blood, improve hem rheological properties and lower triglycerides and cholesterol, in order to effectively treat and prevent diseases.

	Affordable Portable 17 Beam Cold Laser Therapy Knee, Feet, Ankle, Shoulder, Back, Elbow, Hand, Joint & Muscle Arthritis Tennis Elbow Tailbone Inflammation Athletics System Injuries Soft Tissue Injuries Sports Injuries & Sprain Wound & Ulcer Acupuncture Diminish Inflammation More Information Click here
	Four Color 10 Beam 3-in-1 Wrist Laser In another biophysics breakthrough, new research indicates that pulses of visible light from a laser can be used to destroy viruses in biological samples, such as blood. According to reports, the visible light is actually more effective at disrupting the virus' structure than traditional eradication methods, such as UV or microwave irradiation. Those other forms can also trigger mutations within the viruses, perhaps generating resistances More Information Click here
	Finger And Toe Nail Laser Nail fungus is a common condition that begins as a white or yellow spot under the tip of your fingernail or toenail. As the fungal infection goes deeper, nail fungus may cause your nail to discolor, thicken and crumble at the edge. It can affect several nails More Information Click here
	92 Beam Laser Cap Indications: 1. Seborrheic alopecia, alopecia areata, physical alopecia, chemical alopecia. 2. Female postpartum hair loss, female menopause alopecia, sub-health state of hair loss, head mites and head blood circulation poor. 3. Blocked hair follicles, hair roots of malnutrition,hair loss caused by overstrain nerves etc. 4. Hair regrowth. 5. Hair Rejuvenation. 6. Alopecia Areata. 1. Treatment Time:20 Minutes, twice at each week. 2. Easy to use, only button to control the hair laser helmet on/off. 3. 4-18 weeks of oil secretion improved,and hair loss will be back to normal level. 4. 8-26 weeks,hair thicker,more comprehensive(full),more shiny(healthy). 5. 26-52 weeks.the hair comes into the full growth period,and hair volume increased significantly.
	Knee Care Laser Knee Care Laser combines massage, pressure kneading, vibration and Laser irradiation and LED technologies together. It can improve the blood circulation as well as enhance the strength and stability of the Knee More Information here
	Waist Care Laser Waist Care Massager combines massage, pressure kneading, vibration and Laser irradiation and LED technologies together. It can improve the blood circulation as well as enhance the strength and stability of the lumbar region. It plays an important role in supporting and protecting the Lower back as well More Information here
	Low-level laser therapy System The laser probe provides energy with a combination of predominantly laser light (810nm) and peripheral laser light (650nm) diodes to provide a distribution of laser energy over the entire effected area. By applying the laser energy, it triggers normal cellular functions that lead to faster wound healing, pain relief and accelerated functional recovery. It is the most innovative and promising laser therapy device released to date. More Information here