Neurorehabilitation and Neural Repair, Vol. 17, No. 2, 101-108 (2003)
DOI: 10.1177/0888439003017002004
©
2003 American Society of Neurorehabilitation
This Article
PubMed
PubMed Citation
Articles by Scherder, E.
Articles by Sergeant, J.
Effects of Low-Frequency Cranial Electrostimulation on the Rest-Activity
Rhythm and Salivary Cortisol in Alzheimer's Disease
Erik Scherder
Dirk Knol
Eus van Someren
Jan-Berend Deijen
Rob Binnekade
Fred Tilders
Joseph Sergeant
Objective. In previous studies, cranial electrostimulation (CES) had
positive effects on sleep in depressed patients and in patients with
vascular dementia. The present study examined the effects of low-frequency
CES on the rest-activity rhythm and cortisol levels of patients with
probable Alzheimer's disease (AD). Method. It was hypothesised that a
decreased level of cortisol would parallel a positive effect of low-frequency
CES on nocturnal restlessness. Sixteen AD patients were randomly assigned
to an experimental group (n = 8) or a control group (n = 8). The experimental
group was treated with CES, whereas the control group received sham stimulation,
for 30 minutes a day, during 6 weeks. The rest-activity rhythm was assessed
by actigraphy. Cortisol was measured repeatedly in the saliva throughout
the day by means of salivette tubes. Results. Low-frequency CES did not
improve the rest-activity rhythm in AD patients. Moreover, both groups
showed an increase instead of a decrease in the level of cortisol. Conclusions:
These preliminary results suggest that low-frequency CES has no positive
effect on the rest-activity rhythm in AD patients. An alternative research
design with high-frequency CES in AD is discussed.
Key Words: Cranial Electrostimulation • Alzheimer's disease • rest-activity
rhythm • salivary cortisol
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