The research team studied the bone mass and analysed the genetics of a man with enviable health who at the time of the study was 113 years old. The research was carried out with four other members of his family: a 101-year-old brother, two daughters aged 81 and 77, and a nephew aged 85, all of them born and still living in a small town of the island of Menorca. The research findings reported that the man's bones were in excellent conditions: his bone mass was normal, there were no anomalous curvatures and he had never sustained a fracture.

With regard to the genetical analysis, researchers were unsuccessful in finding any mutations in the Klotho gene, which is generally related to a good level of mineral density and therefore healthy bones. Neither did they find any mutations in the LRP5 gene, which is associated with longevity. None of the members of the family who participated in the study presented any mutations in this gene.

The results of the research do not rule out the possibility that other genetic mutations could positively influence longevity. However, researchers do point out the fact that the excellent health of this family, and of the 113-year-old man in particular, is probably due to a Mediterranean diet, the temperate climate of the island, a lack of stress and regular physical activity. The article underlines the fact that until the age of 102, the man cycled every day and looked after the family orchard.

The human life-span and the nature vs nurture question raises the question of why do animals age so differently? Why is it that a tortoise, for example, can live well over a hundred years, while another similarly sized animal would be lucky to live just 10? What’s the big difference?

Scientists say that the secret lies in genetic expression. A new genetic database could help reveal how and why animals age so differently. The process of mapping out this molecular maze will likely unlock some of the hidden secrets of increased longevity in humans along the way.

In some instances, even very closely related animals have drastically different life spans, a fact that has puzzled scientists for years. Mice for example live for about two years while their rodent cousins, the Southern flying squirrel, can live for two decades or so. Chimps and humans are 99 percent genetically identical, so why do humans live twice as long? New databases are helping to identify the genetic expressions that accounts for these vastly varying life spans.

Reverse Ageing

In a study of mice, researchers at Stanford University and the National Institute on Aging (NIA), have now generated a database that catalogues how gene expression, the measure for how active a gene is, changes in various parts of the body as the animal ages. Their findings indicate that different tissues age quite differently over time.

Previous studies have examined how gene expression changes with age in specific parts of the body, such as the brain or the hearts of both mice and humans. But the new study, commissioned by the NIA, simultaneously analyzed the activity of thousands of genes in 16 different tissues at different points during the animals' lives. This has allowed researchers to compare age-related patterns of gene expression between different organs.

The results, published earlier this week in the journal PLoS Genetics, established that the two main culprits previously believed to be primary contributors to the aging process—increased inflammation and slowed metabolism—are indeed guilty parties. But the researchers did find large disparities depending on the different tissues of the body. For example, expression profiles in the liver, brain, and muscle changed little with age, whereas the lungs, eyes, and thymus (an immune organ) experienced more radical transformations.

The researchers compared their results with other previous studies analyzing gene-expression. They analyzed the aging brain, muscle, and kidney tissue in humans, flies, and worms.

Damage to each person’s genome, often called the "Book of Life," accumulates with time. Such DNA mutations arise from errors in the DNA copying process, as well as from external sources, such as sunlight and cigarette smoke. DNA mutations are known to cause cancer and also may contribute to cellular aging.

Now this is where it gets interesting

The researchers found one central theme to gene expression and aging in all four species. They all developed a slowing of the cells’ energy factories.

Georges Lakhovsky In 1925, Georges Lakhovsky published a paper, His expressed philosophy was that “the amplitude of cell oscillations must reach a certain value, in order that the organism be strong enough to repulse the destructive vibrations from certain microbes.” He goes on to say, “The remedy in my opinion, is not to kill the microbes in contact with the healthy cells but to reinforce the oscillations of the cell either directly by reinforcing the radio activity of the blood or in producing on the cells a direct action by means of the proper rays.” Lakhovsky’s Radio-Cellulo-Oscillator (RCO) produced low frequency ELF all the way through gigahertz radiowaves with lots of “extremely short harmonics.” He favored such a wide bandwidth device so that, “The cells with very weak vibrations, when placed in the field of multiple vibrations, finds its own frequency and starts again to oscillate normally through the phenomenon of resonance.” As a result, Lakhovsky’s RCO is now more often called MWO (multiple wave oscillator) for these reasons. We Live on Earth, Why Do We Need Electromagnetic Therapy Devices? This is a very good question. Why is it that we need pulsed magnetic therapy, if we can just go outside and walk barefoot in Nature? Here is the TWO-FOLD problem we have today which can be summarized as Not Enough of the GOOD and too much of the BAD frequencies"

In each species, expression of genes related to energy production dropped twofold by the time the species reached the end of its life span—2 years for mice and around 80 for humans.

A scientist explains it this way. A NORMAL cell has an electrical potential of 70 millivolts, an AGED cell at 50 mV, and a CANCER or ill cell is 15 mV. When a cell is in electrical difficulty the mV and the sodium-potassium balance are out. The high potential brings the cells to an equal level basically resetting them. This allows healing to occur at a higher pace without stressing the cell. And the additional energy restores cell integrity by reorienting it's molecular structure to allow for easier potential movement. Basically it bolsters the field of each cell individually so they support each other more easily...

One professional couple 82 and 73(jewelers still working) have been using the Mwo for 3 years,,, in a phone call he claims his skin had gone back 20+ years

Slow it Down I would like to get some info regarding a device my oncle Nikolas v.. Gu............. (aged 96) bought at your company. He is located in the US is telling his sister, who is my mother and who is located in Europe, Austria – aged 92) about the success he is having with that machine and that he is at least feeling 10 years younger. So my mother also wants to buy this “miracle” machine. Regards, Tina P.............. Steinwandgasse .... Austria

"This is the only common property of growing old between the four different animals," says Stanford biologist, Stuart Kim. "Maybe that should alert us to say there is something unavoidable to getting old."

If, as Bob Beck suggested in his article, the MWO tends to take the body cell back down the time-track to a more youthful, more vital period,

Oops now back to the plot

However, the researchers said there were not a lot of universal similarities, which raises the question of how well lab animals can really serve as models for humans as we attempt to unravel the longevity mystery. For example, studies have found that in humans, and some other animals, that the length of repetitive strips of DNA at the end of each chromosome, also known as telomeres, is linked to aging. However, the researchers didn't find changes in the expression of telomere-related genes in aging mice.

"I wouldn't say that this means that model organisms can't be used to study aging in humans," says Promislow. "It does suggest there is a lot more going on."

This analysis will likely be the first of many to come that will take advantage of this new database, know as AGEMAP. Scientists are still working on figuring out the precise functions of the intertwining genetic networks implicated in aging. AGEMAP serves as a way to decipher differences in genetic expression and better map out the ageing process, especially as it relates to humans.

Click on picture for more information

"The scale of this study is phenomenal," says Promislow. "In some ways, this shows us where things are likely to be headed in coming years in terms of the kinds of experiments people will do to understand the genetic basis of complex traits."

Posted by Casey Kazan with Rebecca Sato.

More Information on the MWO Click here

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