The association recommends "Colloidal Silver Water" of the producer "Eko Solar" from Belgrade, as this product has been assessed and certified as meeting the requirements of ISO 9001:2000 for the production authorized by SGS from Switzerland..
4. Research 4.1 Peculiarities of the therapy of the chronic ethmoiditis when treating "silver people"

Ulyanov Y.P. The XYII World Congr. of Otorhinolaringology.
(IFOS,Sept.28-Oct.3,2002,Cairo, Egypt.)

4.2 Abstract

New data about the successful application of colloidal silver during the process of carrying out therapy for acute rhinitis in "silver people" (Y. P. Uliyanov 1998-2000) allow us to use this effect for treating chronic purulent ethmoiditis (CPE) of the same patient population. It is possible to assign the patients to the group of "silver people" using the author's method of positive response of the nasal mucosae to colloidal silver (5% sol. Collargoli). In the course of examination of 300 such patients with chronic rhinitis, chronic sinusitis was found in 172 patients, from who the CPE was detected at 95 patients. We used 5% sol. Collargoli in the form of drops into the nose 6-8 times per day to treat patients with CPE. At the same time, general antibacterial therapy was carried out. In 77 cases, the recuperation occurred in 3-4 weeks; other patients showed considerable improvement and needed an additional local surgical drainage of the blocked cells of the ethmoid labyrinth (EL). Thus, the colloidal silver eliminates inflammatory rhinedema of "silver people" so effectively that its use in treating chronic sinusitis facilitates the cure of CPE in most of these patients as well.

4.3 Introduction

"For a number of years, the incidence of chronic rhinitis and sinusitis has continued to grow, and this tendency is expected to continue for the next years, in spite of modern achievements of medicinal therapy and endonasal microsurgery"[1,2]. This phenomenon is being explained by the growing deterioration of the ecology, which is well founded, as well as reduced resistance of the cellular system of the nasal cavities to repeated and chronic inflammation processes. This development is the most noticeably reflected in the topographic-anatomic and physiological features of the ethmoid labyrinth, which plays a leading role in formation of chronic sinusitis [3,4]. The narrow ostia of the cellular system of the ethmoid labyrinth provide sufficient drainage of the cells only when they are healthy. However, in the event of acute inflammation of the mucous membrane of the nose, the inflammatory process is likely to become a chronic process in a vicious circle. This is explained by the sharp reduction of the clearance for the ostia of the cells, due to the inflammatory edema of the mucous membrane, which complicates introduction of medications into the cells and leads to a retention of secretions in the cells and is accompanied by an elevation of the pressure in them. And this, in turn, leads to additional activation of the inflammatory process in the closed cellular system with an increase in both the quantity of secretions and the inflammatory edema toward the area of the ostium of the cells, to the point of complete blocking of the inflamed mucous membrane. The inflammatory products accumulating at the site (proteins, lipids, and cell remnants) also condition an inflammatory reaction, development of edema of the mucus membrane, proliferation of fibroblasts, and the simultaneous process of fibrosis leads to irreversible changes in the edematic mucosa in the area of the ostia of the cellular system of the ethmoid labyrinth. Such a closed circle of inflammation easily becomes a chronic condition, and it cannot resolve independently. This was typical for "sauterne" type of nasal aerodynamics, when instead of good ventilation of the ethmoid labyrinth in the "northern" type, when the ethmoid labyrinth was ventilated very actively, the mine air stream upon inspiration passed through the inferior meatus that led to stagnation into the cells of the ethmoid due to the hypoventilathion Only endonasal microsurgery provides a way to drain these impacted cells of the ethmoid labyrinth [5,6,7]. At the same time, the search for new more effective methods of conservative treatment for chronic ethmoiditis is continuing because they are maximally sparing and remains as fundamental for treatment of children. [3]. New information about expressed anti-inflammation efficacy of a preparation of silver (sol. Collargoli 5%) in treatment of acute rhinitis in a separate group of patients called "silver people" has turned out to be useful (Russian Patent N 95112165)[8]. During testing in Russia of 1000 patients with rhinitis and rhinosinusitis, the "silver people" were identified at a rate of 37%. Usage only sol. Collargoli 5% in the form of drops in the nose removed the edema of the mucus membranes and facilitated the rapid reversal of the manifestations of acute rhinitis or exacerbation of chronic rhinitis in these patients (in 2-3 days) [9]..

4.4 Patients and methods

For exposition of the possibilities of use of sol. Collargoli 5% during treatment of chronic sinusitis (ethmoiditis), we conducted further study of this group of patients. Three hundred patients (ages from 2 to 78, the majority of whom were male) were under our observation, having presented in the fall-winter season in connection with acute rhinitis or exacerbation of chronic rhinitis. All these patients belonged to the group of "silver people," according to the results of a positive response of the mucus membrane to introducing drops of sol. Collargoli 5% into the nose. This was expressed by a reduction in the edema of the mucus membrane of the nose, including the lower nasal turbinate, cessation of the secretions from the nose (it became dry in the nasal passages) and reduction of the signs of irritation of the mucus surface. Nasal breathing became freer, the feelings of stuffiness in the nose and heaviness in the head were reduced. Treatment was carried out with introduction 5-6 times of sol. Collargoli 5% into the nose and general anti-inflammatory treatment, which permitted elimination of the manifestation of acute rhinitis and exacerbation of chronic rhinitis in 2-3 days. The acute rhinitis was difficult to distinguish from exacerbation of the chronic condition, since only after elimination of the acute manifestations of inflammation was the subatrophic rhinitis discovered with disturbance of nasal aerodynamics of the "southern" type, when the main flow of air at the inspiration enters through the inferior meatus, causing its overload with subsequent development of acute inflammation in the form of exacerbation of the chronic rhinitis. These violations of aerodynamics of the nose, as we already know, facilitate development of stagnant processes in the sinuses of the nose (ethmoid labyrinth) with development of ethmoiditis due to insufficient ventilation of the middle nasal passageway. Among the group of patients with chronic rhinitis in 252 ( 84%), chronic ethmoiditis was found in 172 patients with purulent inflammation in the ethmoid labyrinth in 95 (from age 8 to 62, more men than women). Having received positive results from treatment of chronic rhinitis and manifestations of exacerbation of the chronic variety with sol. Collargoli 5%, we decided to continue such treatment in persons with chronic ethmoiditis (confirmed by CT scan). Particular attention was paid to the method of introduction of drops into the nose,

because, only sharp nasal inhalation (drawing in) could rise of drops into the middle and superior meatuses, by law of nasal aerodynamics, where the drops intensively were sprayed, covering all the ethmoid cells. In combination with the general anti-inflammatory treatment, 6-8 brief sessions of introduction of drops of sol. Collargoli 5% into the nose led to achievement of positive results of treatment in 2-3 weeks. Deciding of treating for chronic purulent ethmoiditis remained problematic since, for elimination of the purulent process in the nose (the cells of the ethmoid labyrinth), patients were provided introduction into the nose of large doses of strong antibacterial agents, of which the most suitable are antibiotics. However, the antibiotics and other antibacterial agents are absolutely not compatible with sol. Collargoli 5%, which completely destroys them. At the same time, sol. Collargoli 5% itself does not cope with the purulent flora in the blocked cells of the ethmoid labyrinth, and, therefore, with use of the silver-containing drops into the noses which one well uncover ostia of the ethmoid cells of "silver people" patients, we simultaneously introduced large doses of two miscellaneous groups of antibiotics intramuscularly or by mouth.

4.5 Results

During conducting of treatment, already the first two weeks, it was possible to observe significant improvement with cessation of active purulent secretion from the nose and improvement of nasal breathing. Treatment with antibiotics ended a week after disappearance of the purulent secretion in the nose, but the general and local anti-inflammatory treatment continued two more weeks (the cyclic timeframe for the inflammatory process). The results of the treatment were positive in 77 cases (from 95) after 3-4 weeks when it was possible to conduct a full course of treatment (in 6 cases, treatment was interrupted for external reasons). In 12 cases, additional endosurgical drainage of blocked cells of the ethmoid labyrinth was needed and has been performed with good results too.

4.6 Discussion

During analysis of the results received of the trial and treatment of chronic ethmoiditis in "silver people", a number of features become apparent, both the clinical manifestations of this condition and factors of the efficacy of the treatment conducted with use of silver-containing drops (sol. Collargoli 5%). First of all, attention should be paid to the absence in "silver people" of the polypous process in the cells of the ethmoid labyrinth. Only in three cases were there manifestations of hypertrophy of the lower turbinates with reappearance signs of the polypous process. And second, absences of vasomotor disturbances (oedemas) of the nasal mucosae. Therefore, the edema of the nasal mucosa in the area of the ostium of the ethmoid cells could be only an inflammatory development. And this confirms the results of treatment use of sol. Collargoli 5%, which quickly and effectively removes the inflammatory process and inflammatory edema of the nasal mucosas, as well as effectively opens the ostium of the cellular system of the ethmoid labyrinth. Such rapid and effective curing of chronic ethmoiditis, even with purulent inflammatory process can be explained only by the mechanism of effective drainage of the cells of the ethmoid labyrinth. Also, should be in view, that one of the programmed reasons of development of chronic ethmoiditis could be the southern type of nasal aerodynamics and so, the last is needed in additional reconstruction into the "northern" one.

4.7 Conclusions

1. Chronic ethmoiditis in "silver people" advances without the polypous process and without vasomotor disturbances of nasal mucosa, therefore, the edema of mucosa in the area of the ostium of the ethmoid cellular system bears a purely inflammatory character.

2. Use of sol. Collargoli 5% during treatment of chronic ethmoiditis in "silver people" is justified and highly effective, since it allows the realistic possibility of eliminating the inflammatory edema of the mucosa of the ostium of the ethmoid cells, that restores their drainage without surgical intervention.

3. During treatment of chronic purulent ethmoiditis in "silver people," use of silver-containing drops should be recommended for the nose (sol. Collargoli 5%) with simultaneous general antibacterial (antibiotic) therapy.

4. The "southern" type of nasal aerodynamics could be one of the programmed cause of development of chronic ethmoiditis and so, such nasal aerodynamics is needed in additional reconstruction into the "northern" one.

4.8 References

[1] Palchun V.T., Ustyanov Y.A., Dmitryev N.D. Paranasal sinusitides, Ìoscow: 1982, 150. (in Russian)

[2] Piskunov S. Z., Piskunov G. Z., About physiological role of nasal sinuses. Russian Rhinology. 1997;(1):16-7. (in Russian)

[3] Borzov E. V., Sakharov V. I. Nasal sinusitises for children. Russian Rhinology.1997;(2):18. (in Russian)

[4] Piskunov S. Z., Razinkov S. P., Dolzhikova N. V., Tarasov I. V., Korshikov V. N., Elkov I. V. Complex function endoscopically surgery of nose and nasal sinuses. Russian Rhinology.1998;(2):62-3. (in Russian)

[5] Mandy S.H. A new primary wound dressing made of polyethylene oxide gel. Dermatol.Surg.Oncol.1983; 9:153-5.

[6] Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. Cell, Biol. 1994;124:401-4.

[7] Piskunov C. Z., Some anatomic-physiological problems of function rhino-sinus-surgeries. The Russian Rhinology. 1998;(2):62. (in Russian)

[8] UliyanovY.P, Acute rhinitis and drugs of silver. J.Vrach. 1998; (4):40. (in Russian)

[9] UliyanovY.P. Acute rhinitis and silver people among us. Abstract of the report in MidWinter Meeting of ARO. 2000. http://www.aro.org/

4.9 University in Belgrade
SCHOOL OF MEDICINE
INSTITUTE OF PHYSIOLOGY
DEPARTMENT FOR BALNEO-CLIMATOLOGY

University in Belgrade
SCHOOL OF MEDICINE
Number 4/1
December 1, 2005.
BELGRADE

Seal: EKO SOLAR D.O.O.
No. 26-05
December 8, 2005.
Belgrade, Svetog Save 34
Seal:
School of Medicine
University of Belgrade

UNIVERSITY IN BELGRADE
SCHOOL OF MEDICINE
INSTITUTE OF PHYSIOLOGY
DEPARTMENT FOR BALNEO-CLIMATOLOGY
Tel/Fax 3611185 BELGRADE

"EKO SOLAR" limited liability company
Svetog Save St. no.34
Belgrade

Belgrade, November 8, 2005.

RE: Reply to letter of October 9, 2005.

Company "EKO SOLAR" limited liability company, from Belgrade, turned to Institute of Physiology of School of Medicine in Belgrade for their expert opinion on possibilities of everyday use of product "Colloidal Silver Water" and to answer specific questions:
1. Are there established safe doses for consumption of silver?
2. Is silver in the form of water colloid in concentration of 5 mg/l in human organism being deposited or eliminated?

After having inspected documentation on earlier performed corresponding researches, delivered to mentioned company in the form of Research Reports, Opinions and Argumentations of Section for Sanitary Chemistry of the Institute for Hygiene of Department for Preventive Medicine of Military Medical Academy from October 2004, and inspection of voluminous professional and scientific literature, partially presented by the submitter of the request, we are issuing the following:

Expert opinion

Silver is chemical element of 1b group and is located on 47 place of Mendeleyev periodic table of the chemical elements. In cell metabolism silver is necessary microelement, which is not just a catalyst, but is involved in metabolic reactions. Such a fact points out that concentration of silver in human organism is not a constant, but is in direct dependence of intake and the scope of consumption. The consumption being relatively constant, problem appears at adequate intake, considering that, according to natural events, silver is becoming deficient in nutrients. For that reason more frequent symptoms of insufficient intake of this significant vital microelement are being manifested.
Data in literature show very long tradition in application of silver and its compounds, in preventive as well as in therapeutic purposes within human population, even in a very long time period and in official medical science and profession. However, exceptionally fast development of pharmaceutic industry and breakthrough of technologic, not only diagnostic, innovations in medicine like in no other field of science and profession, has pushed silver out of the field of interest of both fundamental and applied medical science. What contributed to that were cases of Argyria - an overdose symptom, where, except for cosmetic no other indications of harmful influence on human organism can be found in the literature. These cases emerged after long-term usage of enormous quantities of silver compound for therapeutical purposes.
Recent researches showed that depots of this microelement in our organism are nervous system, glandular tissue, sclera, subcutaneous fat tissue and bones, but without pathogenic influence in cases of accumulation of increased quantities above normal needs. Negative effects of surplus of silver on function of nervous system, glands or bone marrow have not been proved.
In their efforts to contribute to reduction of deficiency or insufficient intake of silver into human organism consequences, and on the base of sufficient number of researches, World Health Organization and US Food and Drug Agency with the use of NASA experience, have issued precise data on organism needs for this element, problems of intake deficiency and daily needs, which are far beyond doses which may lead to its cummulation.
Recommended doses for normal carrying out of series of enzyme reactions in cell metabolism are 0,014 mg/kg TM. In determination of this dosage considered was a significant fact that in medical practice for centuries back silver has been used as a supplementary therapeutic means in severe infections and in prevention of infections for the purpose of increasing immunologic state of organism in much bigger concentrations, and in completely inadequate forms - in bound form which enabled side effects or effects of new compounds of silver such as silver nitrate, silver acetate, silver protein etc.
The experiences from NASA researches with de-iodinated water enabled use of silver in the form of colloidal solutions. De-iodinated water in which only suspended is silver when particles are of a certain size provides the presence of free silver without the change of liquid color and deposit. So, besides the conditions for emerging effects of pure unbound silver and absence of new compounds, created are conditions for presence of silver in liquid without changed organoleptic characteristics. Colloidal silver liquid, as is usually called, is absolutely transparent, with no smell and with the taste similar to soft low-mineral water, where only a small number of users, experts in biochemistry, may feel a soft metal taste.
Extremely small particles in de-iodinated water with the name Colloidal Silver Water quickly demonstrate its antiseptic local effect, and by its presence in digestive tract, they are quickly reabsorbed and eliminated through urinary tract, without the possibility of deposition. One must emphasize the fact that this elimination process does not make any harm to urinary tract. On the contrary, the presence of silver may ease or intensify therapeutic effects of pharmaco-preparations, which are being used in urinary infection therapy.
Knowledge and experiences acquired through researches of effects on people's health, especially microelements in minerals and spring waters, as well as effects of their deficiency or presence in surplus, great number of data from professional literature (a list is an integral part of this text), as well as the Report on research No. HA 078-1/05 of the Section for Sanitary Chemistry of the Institute for Hygiene of Department for Preventive Medicine of Military Medical Academy of October 22, 2004, absolutely determines suggestion that "Colloidal Silver Water", from the manufacturer the company "Eko Solar", limited liability company, from Belgrade, can be used as a dietary supplement according to instruction for use, which is apparently and clearly placed by the manufacturer, with the remark that with the intake, according to enclosed instruction, deficiencies appeared by decreased content of microelements of silver in the food and drinking water of modern man incompletely compensate, and that the taken quantities considering the form of silver in this preparation sufficient for satisfying intracellular needs, with complete realization of its local antiseptic effects in bodily cavities, which do not belong to inside of organism and achieving effect of increasing the level of general immunologic status of organism, which in present living and weather conditions that surround our area and the most part of population of entire Planet, is of exceptional significance.
If we add the already acquired experience in highly significant results on colloidal silver preparation use in systems for preventing or creating conditions for the less possible virus contamination, carriers of massive pandemic respiratory infections (masks impregnated with this preparation), than the effect is not only medically but financially more significant.
All mentioned, including data from professional literature, is sufficient reason for a conclusion which justifies Official Institutions of Republic of Serbia for issuing of permit and agreement to the manufacturer, the company "Eko Solar", limited liability company, to produce in the form as written on declaration paper, "Colloidal Silver Water" and distribute it to the final user in the manner prescribed by the law, as a dietary supplement, and for that purpose this document may be used. Its eventual use for other purposes such as propaganda or some other way of use on product declaration or public proclamation without special agreement will be considered as act of violation which includes initiating legal procedures.

Signature illegible
Prof. dr. Tomislav Jovanovic, physiologist
Specialist in balneo-climatology

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Signature illegible
Prof. Dr. Tomislav Jovanovic

4.10 University in kragujevac
SCHOOL OF MEDICINE
Department of General and Clinical Biochemistry

EKO SOLAR d.o.o.(limited liability company)
No.28-06
December 4, 2006
BELGRADE, Svetog Save St. no.34

UNIVERSITY IN KRAGUJEVAC
SCHOOL OF MEDICINE
Department of General and Clinical Biochemistry

Company “EKO SOLAR”
Svetog Save St. no.34
Belgrade
November 27, 2006.

Manager of the Company EKO SOLAR from Belgrade, Mrs. Marina Marovic has on November 7, 2006, sent to the Department of General and Clinical Biochemistry of School of Medicine in Kragujevac, formal letter with the request for expert opinion: May people use colloidal silver water for health purposes?

Reply to the letter

Silver (Ag) is chemical element from the group of precious metals. It is limitedly spread in the nature and in low concentration. Besides its presence in the soil, silver is also present in very low concentration (traces) in living organisms (plants and animals) including human organism as well.
Exact biochemical function and physiological effects in which silver would take part have not been completely explained. However, this is not a specificity which applies only to silver. For some other elements (e.g. chromium – Cr) which are found in human organism also are still not known all molecular mechanisms of their affect.
Dynamics of contents of silver in human organism shows that this element has its specific metabolic course when it comes to taking in, absorption, distribution, effect and elimination from organism. Such an approach implies necessity of silver intake into human organism in order to maintain homeostasis and regularity of functioning of the complete organism. Therefore, regular intake of silver is essential for normal functioning of the human organism.
A large number of countries, including also the most developed countries of the Western Europe and America, as well as our country, have officially registered colloidal silver water as nutrient for human use.
Respectable data in professional literature indicate to long tradition of use of various chemical forms of silver for health (preventive) and medical purposes. Preparations used were various chemical forms of salts of silver, most frequently in the form of silver nitrate (AgNO3). Colloidal silver water is the solution of elemental silver in de-ionized water of maximal degree of pureness. This way anionic component of salts of silver in water solutions, is eliminated by which only the use and affect of only elemental silver is enabled.
Besides the use of silver as necessary nutrient, large number of data from scientific literature show that colloidal silver water may be used in treatment or as adjuvant in treatment of large number of different diseases and pathologic conditions.
The most important effect of colloidal silver water is in treating infectious conditions caused by bacteria, fungi and viruses. Such a treatment may be from outside (treatment of skin and mucous membranes) as well as per os (through the mouth) by intake of colloidal silver water in treatment of systemic infectious diseases.
Exceptionally successful results have been achieved in treatment of infections of burns, infections of oral cavity, external part of eye, external auditory canal, digestive tract and genital-urinary tract.
Successful treatment of infectious diseases by application of colloidal silver water comes from affect of silver directly on destruction of pathogenic microorganisms as well as satisfactory influence of silver on stimulation of immunologic mechanisms of human organism.
Although so far there are neither plenty data in professional literature nor clinical researches of therapeutic effects of colloidal silver water, published results state that with all systemic auto-immune diseases and degenerative diseases, effect of colloidal silver water is very favorable.
So far have not been recorded cases of intoxication (poisoning) with colloidal silver water. In professional literature have been mentioned rare examples of persons who have consumed in high concentrations and during longer period, preparations made on their own and with silver preparations which they made by themselves. Such individuals have developed symptom called Argyria. This symptom is mild grayish-blue coloring of the skin and of visible mucous membranes due to accumulation of silver or due to specific and presently unknown mechanisms of effects of silver on mucous membranes, skin and subcutaneous tissue. However, in spite of consummation of exceptionally high doses of silver, such individuals have neither demonstrated symptoms of intoxication nor other symptoms of disorder in functioning of organism.
Answer to a question: May people use colloidal silver water for health purposes?, is positive.
Due to the reduced resources of silver in the soil, necessary quantities of silver indispensable for normal functioning of human organism are not taken into the body by usual nutrition. Therefore, the use of colloidal silver water is very useful for preventive reasons. In addition to that, the use of colloidal silver water is useful in treatment of or as adjuvant in treatment of large number of infectious and systemic diseases.

Signature illegible
Prof. dr. Tomislav Stojanovic
Head of the Department for General and Clinical Biochemistry
of School of Medicine in Kragujevac

4.11 Efficiency of colloidal silver water in therapy of acute urinary infections

EKO SOLAR d.o.o.(limited liability company)
No.26-07
July 2, 2007
BELGRADE, Svetog Save St. no.34

EFFICIENCY OF COLLOIDAL SILVER WATER IN THERAPY OF ACUTE URINARY INFECTIONS

At the Clinic for Infective Diseases in Kragujevac, research was carried out on efficiency of application of colloidal silver water as adjuvant therapy in treatment of urinary infections with hospitalized patients and outpatients. The goal of research was to establish significance of its application in treatment of urinary infections.
Diagnosis of urinary infection was established on the basis of present subjective discomforts which pointed out to dysuric discomforts (painful and frequent urination), examination of sediment in urine, biohumoral syndrome of inflammation (leukocytosis, increased value of CRP and quickened SE) and urino-culture. On the basis of the gravity of the disease, biohumoral syndrome of inflammation and systemic signs of infection, diagnosis was established as Cystitis acuta and Pyelonephritis acuta.
Testing included 30 patients. We divided all patients into three groups, 10 patients in each group. To the first group of patients was ordinated colloidal silver water in the dose of 2 teaspoons every two hours while discomforts last and after that, 2 teaspoons three times a day. To the second group of patients, besides colloidal silver water, was also ordinated antibiotic because of the gravity of the disease and systemic signs of infection. Third group of patients received only antibiotic.
We made evaluation of the efficiency of the applied therapy with all patients after five days (sediment of urine, urino-culture) and with some biohumoral syndrome of inflammation as well. Results of testing showed that in the first group of patients with DG Cystitis acuta, colloidal silver water was very successful because with 8/10 patients subjective discomforts disappeared, occurred sterilization of urine culture and normalization of findings in the sediment. In the second group of patients with DG Pyelonephritis acuta application of antibiotics and colloidal silver water showed success at 7/10 patients. In the third group of patients with DG Pyelonephritis acuta to which only antibiotic was administered normalization of findings in the sediment of urine and sterilization of the culture occurred with 4/10 patients, which indicates to significant efficiency of colloidal silver water as adjuvant therapy in treatment of grave urinary infections.
On the basis of the achieved results we may conclude that by application of colloidal silver water was achieved significant success in treatment of patients with mild urinary infection, and in combination with antibiotic in grave urinary infections.

In Kragujevac
On May 25, 2007.

Prof. dr Olgica Gajovic
Specialist in Infectious Diseases
Signature illegible

Seal: Docent Dr Olgica Gajovic
Specialist in Infectious Diseases