(1.Hospital of South China Normal University, Guangzhou 510631, Guangdong, China;

2. Beijing Liferun Medical Science Ltd., Beijing 100089, China; 3. School for Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, Guangdong, China)

 

Abstract: Objective: To explore the effects of low-intensity laser nasal irradiation (650nm/5mW) on dyslipedemia. Methods: Thirty cases with dyslipidemia were randomized into two groups: drug group and laser group. Simvastatin was taken by the drug group and the laser group received the low-intensity laser nasal radiation therapy. The serum lipid was measured before and after the treatment.

 

Results: Based on the food control, TC level of the laser group dropped 5.8% (P=0.031), and TG dropped 8.8%. And at the same time the ALT level of the laser group dropped 23.1% (P=0.022), which meant that the laser therapy could protect the liver function.

  

Low-intensity laser irradiation has various bio-effect, present study showed Intra-vascular Low lever Laser Irradiation (ILLLI) has obvious therapeutic effects on ischemic cardiac and cerebral vascular diseases^[1,2]. Base and clinical research indicate that ILLLI can improve hemorrheological properties, improve blood circulation, especially microcirculation; regulate immunity; enhance enzyme activity, detoxify; this eliminate free radical, restrain formation thrombus, enhance activity of enzyme Na⁺-K⁺-ATP in red cell membrane, raise level of SOD (this enzyme can eliminate free radical), which helps eliminate free radical, anti-old, improve blood hyperkinesias; it can also increase red cell metabolic ability, improve hemorrheological properties, decrease blood viscosity; regulate fibro-lysis and other bio-effects^[3-5].

Low-intensity laser nasal irradiation is developed on the basis of ILLLI. Because nasal epidermis is very thin, and many blood vessels in the mucous membrane, blood flows very slowly, Low-intensity Laser Nasal Irradiation with Nose Head Cover has a large irradiation area with good penetration of 650nm laser, which guarantee laser contact blood components completely. Low-intensity Laser Nasal Irradiation Therapy is of no cut, no pain and no medicine side effect and suitable for home use. On the basis of mentioned above, this study of low intensity laser nasal irradiation therapy on dyslipidemia. Take 30 patients with primary dyslipidemia as two groups, treat them by low intensity laser nasal irradiation and common medicine, and observe the effects.

 

1.1 Patients Selection

Patients is selected according to ¡°Prevention and Treatment Suggestion on Dyslipidemia¡± by

China cardiac vascular Journal committee. The following patients is excluded: age of lower than 18 or older than 70; Pregnant and nursing women; acute cardiac infarction, severe injury in cerebrovascular accident or unsteady diseases after operation; dyslipedemia and hypercholesterolemia caused by Nephrotic Syndrome, hypothyroid hypergasia, acute or chronic liver and gall diseases diabetes; dyslipidemia caused by medicine; patients who is in medicine period of heparin, thyroid hormone medicine and other medicine which affect blood fat metabolism; patients with primary diseases and psychosis of liver and kidney and Hematopoietic system.

1.2 Patients Group

Divide 30 patients with primary dyslipidemia into two groups: Drug and laser. Average age: Laser Group 57.8 ¡À 9.8, Drug Group 55.0 ¡À 7.2. Treating the common data of the two groups statistically, there was no significance difference (P>0.05). So it has comparability.

 

Low-fat diet were used in two groups.

2.1 Drug Group

Vastatin drug¡ªShu jiangzhi is used in this study. Dosage: once each day, 20mg/time, take at night, continuously used for 19d.

2.2 Laser Group

Low intensity laser nasal irradiation. Laser wavelength is 650nm and power is 5mW. Irradiate for 45 mins each time. Once a day, 7d a course, and after that 5d interval, two courses totally 19d. Low intensity laser treatment instrument

2.3 Observe Item

Blood drawing examine is conducted on 1^st d and 20^th d. examine items includes: TC, TG, HDL-C, LDL-C, ALT, AST etc).

2.4 Statistics Method

SPSS10.0 software and Analysis Of Variance or T Test is adopted; Analysis of covariance is used in difference between blood fat level and liver function before and after treatment. Matched T test is adopted to compare difference between blood fat level and liver function before and after treatment.

 

3.1 Comparison of Blood Fat Level

Baseline of laser group and blood fat level of after treatment is as Table 1, blood fat level is obviously improved after 2 course laser treatment.

                Table 1  Serum lipid of the patients in laser group                        

Baseline        6.22 ¡À 0.90   2.52 ¡À 1.28     1.45¡À0.50       3.65 ¡À 0.98

On the 20^th Day  5.83 ¡À 0.86   2.05 ¡À 1.12      1.27 ¡À 0.36         3.64 ¡À 0.97

 

3.2 Comparison of Therapeutic Effects

Analysis of covariance is used to compare therapeutic effect difference between two groups, the result show that blood fat level of the both groups all improved, but drug group improved more significantly, on 20^th day TC, HDL-C, LDL-C improvement rate has significant difference with laser group. Table 2 shows blood fat decreasing rate compared with baseline after treatment.

Laser Group    -5.8 ¡À 8.5    -8.8 ¡À 39.9      -7.2 ¡À 29.7          6.4 ¡À 42.1

Drug Group    -23.7 ¡À 6.8   -16.0 ¡À 26.6      5.4 ¡À 13.4         -32.3 ¡À 15.5

 

3.3        Comparison of ALT level

ALT level decrease significantly after treatment in laser group (P=0.022), but no

Obvious change in drug group, see Table 3.

 

                      Laser Group                     Drug Group

Baseline         22.4 ¡À 11.2   23.9 ¡À 6.7      27.9 ¡À 10.726.1 ¡À 6.2

On the 20^th day   17.0 ¡À 10.7   24.0 ¡À 7.5          27.7 ¡À 6.9   28.9 ¡À 7.2

 

3.4  Comparison and Analysis of Safety of the Two Groups

Analysis of covariance is used, after adjustment of age, gender, smoke, drink and waistline and other probable factors, after laser treatment, ALT decrease obviously, and much better than drug group (P= 0.070), and change of AST of the both group is similar. Table 4 is decreasing rate of ALT before and after treatment.

 

Laser Group           -23.1 ¡À 28.2             0.5 ¡À 15.6

Drug Group            6.9 ¡À 27.7              15.0 ¡À 40.1

 

Dyslipidemia will lead to coronary heart diseases, cerebrovascular accident and other cardiac & cerebral vascular diseases. Tatin drug can obviously reduce fat, but accompanied with side effect as liver function lesion and Rhabdomyolysis etc.

The result of this study shows: on the basis of diet adjustment, low intensity laser nasal irradiation decrease serum TC level by 5.8% (P=0.031), TG decrease by 8.8%; low intensity laser nasal irradiation therapy can effectively regulate blood fat and ALT level decrease 23.1% (P=0.022), which has protective function to liver. This study only observe two courses (Totally 19 days) effects, the result indicates that long blood fat reduction therapeutic effects of laser nasal irradiation worth further observation.

Compared with Shu Jiangzhi, the effect of blood fat regulation by low intensity laser nasal irradiation is relatively weaker, but on consideration of safety, for the patients who get no effect by diet control or abnormal liver function, low intensity laser treatment has a great applicative value. Meanwhile, this study also has enlightened course arrangement and treatment features for low intensity laser nasal irradiation.

 

 

 

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